Unveiling the proteomic landscape of multiple sclerosis: A comparative analysis in two mouse models
Sonsoles Barriola, Lina Delgado-García, Paz Cartas-Cejudo, Ignacio Iñigo-Marco, Joaquín Fernández-Irigoyen, Enrique Santamaría, Laura López-Mascaraque · FENS Forum 2024
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder of the central nervous system (CNS), a heterogeneous disease that courses with both demyelination and inflammation. We used two different animal models to recapitulate different aspects of this disease, experimental autoimmune encephalomyelitis (EAE) and cuprizone (CPZ) induced demyelination. To study the differential response of the CNS, we compared the proteomic profile of EAE mice (at peak disease) and CPZ mice (in the acute phase) in two different CNS regions: somatosensorial cortex (Cx) and spinal cord (SC). Our resul
ePoster · Neuroscience