Assessment of metabolome in the tumor microenvironment by cerebral open flow microperfusion (cOFM) in a human glioblastoma xenograft animal model
Thomas Altendorfer-Kroath, Denise Schimek, Fernanda Monedeiro, Elmar Zügner, Eva-Maria Prugger, Christoph Magnes, Thomas Birngruber · FENS Forum 2024
Orthotopic xenograft studies strongly promote the development of personalized and targeted cancer therapies to increase the still very poor life expectancy of glioblastoma (GBM) patients. As the tumor microenvironment (TME) plays an active role in cancer progression, the TME has increasingly become subject of investigations recently.We aimed to assess the metabolome from interstitial fluid (ISF) collected with Open Flow Microperfusion (cOFM) from the TME and compare it to the metabolome from cerebrospinal fluid (CSF). This was done via atraumatic access that has been generated by inoculating m
ePoster · Neuroscience