Topic: OSK

Alzheimer Disease (AD) is the most prevalent form of dementia, and treatments aiming to counteract its effects are missing. Recently, neurons responsible for memory formation (i.e., engrams cells) have been shown to be impaired in mouse models of AD, but no sustained means to rescue their function, and thereby mnemonic capacities are available to date. While partial cellular reprogramming through induction of the Yamanaka Factors (Oct-4, Sox-2, Klf-4 and c-Myc – OSKM) has recently emerged as a promising tool to counteract the systemic effects of aging, reprogramming of specific cell types or i