Effects of methylcobalamin on bone formation via peripheral nerves and macrophages
Toshiki Shimada, Toru Iwahashi, Yoshiaki Yoshimura, Katsuyuki Konishi, Atsushi Kamata, Mai Konishi, Arisa Kazui, Ryoya Shiode, Satoshi Miyamura, Kunihiro Oka, Seiji Okada, Hiroyuki Tanaka · FENS Forum 2024
Aim: Methylcobalamin (MeCbl) is known to promote peripheral nerve regeneration and polarize macrophage to M2. In recent years, it has been reported that the regeneration of peripheral nerves and the polarization of macrophages to M2 are important for bone formation. The purpose of this research is to examine the effects of MeCbl on bone formation via peripheral nerves and macrophages. Methods: Effects of MeCbl were evaluated using rat skull defect models. Briefly, we created a bone hole in the rat skull, and evaluated the bone formation rate in the defect area in a group that received continuo
ePoster · Neuroscience