Osteogenesis imperfecta: A look into the brain of a murine model
Enrico Pelloni, Claudio Casali, Roberta Besio, Gloria Milanesi, Wendy Perez Franco, Federica Gola, Ludovica Gaiaschi, Margherita Cavallo, Antonella Forlino, Maria Grazia Bottone, Fabrizio De Luca · FENS Forum 2024
Osteogenesis imperfecta (OI) is a complex disease caused by changes in connective tissue composition, leading to bone fragility. The pathophysiology of this disorder is highly diverse, involving a range of genetic variables and a variety of phenotypic symptoms, including neurological impairment.Our research focused on the possible alteration that occurred in the Central Nervous System (CNS) of an in vivo model of OI, using male and female adult Brtl-/+ mice. Histochemical techniques were employed to investigate the morphological changes of CNS, through Hematoxylin & Eosin and Picrosirius r
ePoster · Neuroscience