The inhibitor of bromodomain and extraterminal domain (BET) proteins, OTX-015, mitigates the hippocampal amyloid-β load in mice subjected to prenatal stress
Grzegorz Czapski, Marta Matuszewska, Elżbieta Gawinek, Magdalena Gąssowska-Dobrowolska, Anna Wilkaniec · FENS Forum 2024
A growing body of evidence indicates a substantial role of the immune system and inflammation in the pathogenesis of Alzheimer’s disease (AD). In the current study, we investigated the effect of maternal immune activation (MIA) on AD-resembling pathological alterations in 12-month-old offspring. We also aimed to analyze whether inhibition of bromodomain and extraterminal domain (BET) proteins, the readers of the histone acetylation code, might impact these changes. In our study, we injected a viral mimetic polyinosinic-polycytidylic acid (PIC) at gestation day 17 to evoke MIA in wild-type mice
ePoster · Neuroscience