Flexible decision-making engages generalizable spiraling dynamical motifs in prefrontal cortex
Xulu Sun, Alison Comrie, Emily Monroe, Ari Kahn, Abhilasha Joshi, Jennifer Guidera, Lulu Tong, Eric Denovellis, Timothy Krausz, Joshua Berke, Nathaniel Daw, Loren Frank · COSYNE 2025
The prefrontal cortex (PFC) is critical for flexible decision-making, and dynamical motifs have been identified in PFC population activity that could support certain aspects of this process (e.g., context-dependent line attractors for sensory input integration). PFC is also known to encode a plethora of decision-relevant variables, including task progression, action, and value. It remains an open question whether there are dynamical motifs that track all these variables to inform decisions. Further, it is unclear how outcome feedback alters neural representations of these variables and impacts
ePoster · Neuroscience