Restraint stress-induced antinociceptive effects in acute pain: Involvement of orexinergic system in the nucleus accumbens
Amir Haghparast, Danial Farmani, Seyed Mohammadmisagh Moteshakereh, Mohammad Nikoohemmat, Abbas Haghparast, Sakineh Salehi · FENS Forum 2024
The studies demonstrated that the nucleus accumbens (NAc) is critical in modulating pain and stress-induced analgesia (SIA). As a neuropeptide, orexin is crucially involved in initiating behavioral and physiological responses to threatening and unfeeling stimuli. However, the role of the orexin receptors of the NAc area after exposure to restraint stress (RS) as acute physical stress in the modulation of acute pain is unclear. The 23-gauge guide cannula was unilaterally implanted intra-NAc. The SB334867 and TCS OX2 29 were used as antagonists for OX1r and OX2r, respectively. Different doses of
ePoster · Neuroscience