Orexin-2 receptor protein levels in the thalamocortical axis in genetic absence epilepsy rats from Strasbourg
Devrim Oz Arslan, Nursima Mutlu, Özge Sariyildiz, Musa Çelik, Zoltan Molnar, Nihan Çarçak, Filiz Onat · FENS Forum 2024
The lateral hypothalamus produces the neuropeptides orexin-A and -B, also referred to as hypocretin-1 and -2, which activate the OX1 and OX2 receptors. The orexin system is linked to various neurobiological processes and specifically plays a critical role in regulating the sleep-wake cycle. Epilepsy, as a frequent neurological disease, affects people of all ages. Given that epilepsy can impact sleep in multiple ways, the relationship between the orexinergic system and the pathophysiology of generalized epilepsies remains to be determined.We investigated the orexin-type 2 receptor (OX2R) in the
ePoster · Neuroscience