The analysis of the OXT-DA interaction causing social recognition deficit in Syntaxin1A KO
Tomonori Fujiwara, Kofuji Takefumi, Tatsuya Mishima, Toshiki Furukawa · FENS Forum 2024
Recent studies revealed that the dysfunction of post-synapse and/or pre-synapse related to neuropsychological disorder such as autism spectrum disorders (ASD). HPC-1/syntaxin1A (STX1A) is known to regulate neurotransmitter release at pre-synaptic terminal. Previously, we found that some ASD patients were haploid for STX1A gene. We also reported that STX1A gene knockout mice (STX1A KO) showed unusual behavioral profiles similar to human ASD patient. Interestingly, the deficit of social recognition, one of the unusual behavior in STX1A KO, partially ameriolated with dopamine (DA) receptor agonis
ePoster · Neuroscience