A “breathing” brain model: Metabolic measurements in whole-brain organoids
Sonia Cerchio, Ermes Botte, Gemma Gomez Giro, Jens C. Schwamborn, Arti Ahluwalia, Chiara Magliaro · FENS Forum 2024
Brain organoids represent a promising technology in neurosciences, due to their capability of resembling salient human brain structural and functional features in vitro. For this reason, they are successfully employed for gaining hitherto insights in human brain. Several brain pathologies – among all, Parkinson’s Disease - are linked to metabolic alterations. However, the ground truth for measuring metabolism in vitro - i.e., platforms such as the Seahorse Analyzer - monitors nutrient consumption at a bulk level, without locally mapping concentration changes. This approach cannot provide an ex
ePoster · Neuroscience