Inhibitory synapses on spinal motoneurons express VAMP1 and VAMP2 and both are reduced by tetanus toxin while sparing these same VAMPs in adjacent excitatory synapses
Paula M Calvo, Ryan L Wood, Francisco J Alvarez · FENS Forum 2024
Tetanus Neurotoxin (TeNT) enters the peripheral endings of motor axons in muscles and transports to motoneuron cell bodies where transynaptically translocates to presynaptic inputs blocking inhibitory synapses. This disinhibits motoneurons causing dysregulated firing and tetanic contractions. Preferential actions on inhibitory synapses are usually explained by enrichment in the Vesicle-Associated Membrane Protein 2 isoform (VAMP2). VAMP1 and VAMP2 form part of the SNARE complex and are differentially distributed in different synapses. Nevertheless, the exact VAMP content inside synapses on mot
ePoster · Neuroscience