Phosphorylated protein tyrosine kinase 2 exhibits altered expression in a region-specific manner in temporal lobe epilepsy
Ozasvi Rajeev Shanker, Sonali Kumar, Jyotirmoy Banerjee, Manjari Tripathi, P.Sarat Chandra, Fouzia Siraj, Aparna Dixit · FENS Forum 2024
Temporal lobe epilepsy (TLE) is one of the most common forms of drug-resistant epilepsy and its precise etiology is still unknown making it imperative to understand the molecular pathways contributing to the disease. It is, therefore, crucial to study the therapeutic targets and signalling pathways involved in the treatment of this disease. Pyk2 has previously been shown to be activated in stress-mediated pathways in the brain. Consequently, we hypothesized that Pyk2 activation might contribute to the pathogenesis of the disease. A pilocarpine model of TLE was used to examine p-Pyk2Tyr402 prot
ePoster · Neuroscience