Oxytocin and leptin crosstalk in the regulation of the energy balance
Chiara Galli, Georgia Colleluori, Simone Moretti, Valentina Cinquina, Roman A. Romanov, Jessica Perugini, Ilenia Severi, Gabriele Cruciani, Tibor Harkany, Antonio Giordano · FENS Forum 2024
Oxytocin (Oxt) is a hormone produced in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus, known to mediate the central anorexigenic effects of the adipokine leptin (Lep), as well as to promote adipose tissue (AT) lipolysis at the periphery. Here, we sought to address whether Oxt neurons could directly respond to Lep, and if any such regulatory cascade would increase Oxt levels in plasma. Adult C57BL/6 mice were intraperitoneally injected with mouse recombinant leptin (0.5 mg/kg) or saline, while others were subjected to standard or high-fat diet (HFD). Hypothalamus, AT
ePoster · Neuroscience