Topic: p53 signaling

Embryonal Tumors with Multilayered Rosettes (ETMR) are a diverse and rare, but highly aggressive, form of embryonal brain tumors. All ETMRs share common histological and transcriptomic traits such as the presence of highly proliferative rosettes and aberrations on relevant miRNAs signaling pathways, including depletion of let-7 family miRNAs and increased Lin28A expression. Two different genetic alterations have been found to underlie ETMR tumors: amplification of the C19MC microRNA cluster, and biallelic Dicer1 inactivating mutations. Remarkably, a faithful animal model recapitulating this pa