PACAPergic brain projections to the ventral respiratory column
Alice Oh, Ayse S. Dereli, Irit Markus, Simon McMullan, Natasha N. Kumar · FENS Forum 2024
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide involved in neonatal CO2-stimulated respiration. The ventral respiratory column (VRC), which contains the core inspiratory rhythm generator, receives PACAPergic inputs from the retrotrapezoid nucleus (RTN) and expresses PAC1 receptor in neonates. However, in adults, the afferent origins of PACAPergic transmission to the VRC other than the RTN; and PACAP expression changes in response to chronic hypercapnic conditions are unknown.Using cholera toxin subunit B (CTB) mediated retrograde neuronal tracing and in situ hybri
ePoster · Neuroscience