PACAP at the crossroads: Interplay and synergy with other neuropeptides in headache disorders
Maxim Tollenaere · FENS Forum 2024
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), Calcitonin Gene-Related Peptide (CGRP) and Vasoactive intestinal peptide (VIP) are multi-functional neuropeptides that have been linked to debilitating conditions such as migraine. Moreover, Anti-PACAP and anti-CGRP antibodies have demonstrated clinical efficacy in Phase II and Phase III trials for treatment of migraine, respectively. Due to considerable homology and structural similarities, VIP and PACAP can bind to and signal via the same three functional G-Protein Coupled Receptors (GPCR), PAC1R, VPAC1R and VPAC2R. CGRP on the othe
ePoster · Neuroscience