Comparative examination of the ventral tegmental area in wild type and pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice
Pham Dániel, Schmidt Marcell, Fülöp Dániel Balázs, Gaszner Balázs, Tóth Tünde, Reglődi Dóra, Andrea Tamás · FENS Forum 2024
PACAP is a neuroprotective peptide in Parkinson’s disease models. Earlier we compared the substantia nigra of PACAP knockout (KO) and wild type mice (WT) of different ages and did not find significant changes in the cell number of dopaminergic neurons, but in ageing PACAP KO mice we detected higher number of resting microglia. Our aim was to examine the ventral tegmental area (VTA), which has important function in the regulation of social behavior.We examined the VTA of WT [n=5-5-5] and PACAP KO mice [n=5-4-5] aged 1.5,4, and 8 months. We used triple labelling, dopaminergic neurons were staine
ePoster · Neuroscience