Neuroinflammatory mechanisms of pain hypersensitization in a mouse model of ADHD
Sarah Bou Sader Nehme, Sandra Sanchez-Sarasua, Mairead Sullivan, Jeffrey Glennon, Eric Boué-Grabot, Walid Hleihel, Marc Landry · FENS Forum 2024
Attention-deficit/hyperactivity disorder (ADHD) is a common multifactorial neurodevelopmental disorder, with a prevalence of around 8% in children worldwide. It is characterized by symptoms of inattention, hyperactivity, and impulsivity and is usually associated with cognitive, emotional, and behavioral deficits. Clinical studies suggest that pain hypersensitivity develops in subjects with ADHD. However, the mechanisms and neural circuits involved in these interactions remain unknown. Our team has previously validated a mouse model of ADHD obtained by neonatal 6-hydroxydopamine (6-OHDA) intrac
ePoster · Neuroscience