Topic: pair-patch clamp

The fundamental language of the brain is articulated by timing and frequency patterns of neuronal output that are interpreted by receiving neurons through a basic mechanism known as short-term plasticity (STP). However, these synaptic dynamics exhibit considerable heterogeneity both within and across genetically defined cell types which poses a critical barrier to interpreting this language. Beninger et al. addressed this heterogeneity in excitatory human and rodent synapses by organizing their dynamics into functional subtypes which cannot be explained by continuum hypotheses and partly overl