Topic: paired-pulse plasticity

Hypoinsulinemia is a pathological consequence of diabetes mellitus that can stimulate the development of neurodegenerative processes in the brain due to dysfunction of insulin signaling cascades into neurons and impaired synaptic plasticity properties. We used the whole-cell patch-clamp recording of evoked glutamatergic excitatory postsynaptic currents (eEPSCs) with the local stimulation of presynaptic axon to investigate the insulin (100 nM) effect on the paired-pulse plasticity at cultured hippocampal neurons under hypoinsulinemia (4 days insulin-free media incubation).At control normoinsuli