Topic: pancreatic encephalopathy

Acute pancreatitis (AP) is an inflammatory gastroenterological disease, during which about 4% of all patients develop disturbance in consciousness. Besides this sypmtom among the severe AP cases 10 % show serious neurological involvement manifesting in pancreatic encephalopathy. Earlier research from our laboratory showed blood-brain barrier (BBB) permeability elevation in a rat non-invasive AP model. Now our goal was to identify potential BBB injury in pancreatitis patients. For this study we used serum from mild, moderate and severe AP patients to identify BBB opening by measuring neuron spe