Crosstalk between glial Cx43 hemichannels and neuronal Panx1 hemichannels and P2X7 receptors orchestrates presynaptic homeostatic plasticity
Alberto Rafael, Marina Tizzoni, Andrea Cairus, Verónica Abudara, Nathalia Vitureira · FENS Forum 2024
In recent years, a pivotal role of gliotransmission in homeostatic synaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor. However, very little is known about the glial non-vesicular ATP-release pathway and how ATP participates in the modulation of synaptic strength. In this work, we have analyzed the functional changes occurring in neurons upon chronic activity blockade and the role of the purinergic signaling, connexin43 and pannexin1 hemichannels in this process. By using hippocampal dissociated cultures, we showed that blocking connexin43 and pannexin1 h
ePoster · Neuroscience