Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice
Aitak Farzi, Grace Bukowski-Thall, Frederike Fellendorf, Sarah Gorkiewicz, Marija Durdevic, Sabrina Mörkl, Jolana Wagner-Skacel, Susanne Bengesser, Melanie Lenger, Nina Dalkner, Gorkiewicz Gregor, Tobias Madl, Christine Moissl-Eichinnger, Eva Reininghaus · FENS Forum 2024
Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes of depression and (hypo-) mania. The gut microbiome is a potential avenue through which metabolic signaling, inflammatory pathways and environmental factors influence mood disorders via the gut-brain axis. Fecal microbiota transplantation (FMT) is a translational tool for investigating the connections between the gut microbiome and the brain, and there is evidence that FMT from humans to mice can induce changes in affective behavior. In this study, we compared the behavior, gut-brain metabolomic profiles, and
ePoster · Neuroscience