Topic: Parasagittal organization

Parasagittal organization is an evolutionarily conserved, fundamental feature of the cerebellar cortex. It is visualized by molecular markers, myelination differences, input and output pathways and susceptibility to degeneration. Different Purkinje cell subpopulations based on molecular marker expression have been shown to exhibit differences in baseline physiological properties, developmental timeline and synaptic plasticity. These subpopulations have also been linked to different cerebellar-dependent learned behaviors. In this study, we demonstrate that these subpopulations exhibit unique ph