Age-related differences in pupil dynamics assessed with cognitive pupillometry
Adrian Ruiz Chiapello, Enzo Buscato, Alexandra Pressigout, Isabelle Berry, Andrea Alamia, Florence Remy · FENS Forum 2024
Locus coeruleus (LC) activity consists in a sustained low-frequency firing rate (tonic activity), accounting for basal pupil diameter, interspersed with event-driven higher-frequency bursts (phasic activity), accounting for event-related transient changes in pupil diameter. Pupil size measurements are used here as a non-invasive biomarker of LC activity, and to assess its evolution with age. Pupil size was measured in 72 healthy participants (34 young: age = 23.0 years ± 2.6; 38 older: age = 69.3 years ± 6.8), who underwent a 2-minute passive gaze fixation task and a fast object categorization
ePoster · Neuroscience