Topic: parkinsonian-like metabolic profile

Parkinson’s Disease (PD) is a progressive and incurable neurodegenerative disease characterized by an irreversible loss of nigrostriatal dopaminergic neurons. Its symptomatology evolves over the years from a prodromal stage, including neuropsychiatric symptoms such as loss of motivation and anxiety, to a clinical stage with significant motor impairments. Today, the causes of PD pathogenesis are still poorly understood. In this context, we recently performed a translational metabolomic study using PD patients and rat models, which revealed a decoupling between the glycolysis and the Krebs cycle