Topic: Parvalbumin-expressing chandelier cells

During cortical development, GABAergic interneurons refine their connectivity in response to changes in activity of their postsynaptic targets, contributing to the establishment of functional neural circuits. Parvalbumin-expressing chandelier cells, a GABAergic interneuron subtype that forms axo-axonic synapses at the axon-initial segment (AIS) of pyramidal neurons, are optimally positioned to regulate network-wide spiking activity. It has been shown that chandelier cells change the number and density of their axon-targeting synapses onto L2/3 pyramidal neurons following chronic changes in net