Whole-brain perineuronal net and parvalbumin expression analysis in Fragile X syndrome mice
Lorenzo Cifarelli, Alessandra Oberto, Francesca Dosio, Jacopo Pinto, Francesco Castano, Federico Luzzati, Ilaria Bertocchi · FENS Forum 2024
Fragile X syndrome (FXS), caused by inactivation of Fmr1 gene, is the most common cause of intellectual disability and autism spectrum disorder. Fmr1 knockout (Fmr1KO) mice display a disorganization of perineuronal nets (PNNs), specialized forms of extracellular matrix which form around neurons during postnatal development in many brain areas. These nets are preferentially established around Parvalbumin-positive GABAergic interneurons (PVIs), and their presence reduces brain plasticity. PNN and PVI expression is altered in various neuropsychiatric disorders and in some cases their manipulation
ePoster · Neuroscience