Topic: patch-clamp

G-Protein coupled receptors (GPCRs) are among the most prominent receptors in the central nervous system. Their malfunction is implicated in various neurological and neuropsychiatric disorders, making them a common target for medical treatment. Thus, it is crucial to gain a comprehensive understanding of GPCR functions and mechanisms to develop more effective and targeted medical treatments with fewer side effects.This study examines the potential interplay between the serotonin receptors 5-HT1A and 5-HT2C, which play a significant role in the pathology of depression. Experiments were performe

El aprendizaje y la memoria son esenciales para la interacción con el medio ambiente y para la supervivencia de la especie. Estas funciones cognitivas parecen requerir que el hipocampo y la corteza entorrinal (CE) procesen información sensorial, espacial y temporal. Se supone que las sinapsis de la capa EC III (ECIII) -CA1 son necesarias para la memoria asociativa temporal, que incluye subtipos de recuerdos como la memoria de trabajo que puede estar involucrada en la enfermedad de Alzheimer. Aquí queríamos conocer el mecanismo de LTP en las sinapsis EC LIII-CA1, para ello utilizamos la técnica

The study focuses on the central role of the medial septum (MS), a critical component of the basal forebrain nucleus, in supporting various physiological activities such as sensorimotor integration and memory consolidation. The primary goal is to unravel the intricate information transfer mechanism between the MS and the hippocampus during memory formation, with a particular focus on the involvement of MS neurons in both hippocampal theta wave and ripple generation.To achieve this goal, a patch-clamp methodology was used for in vivo recording of MS neuronal activity. This approach was designed