Topic: patch clamp technique

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by early non-cognitive dysfunctions. Recent studies have reported synaptic alterations in limbic circuits in AD animal models, even before amyloid plaque appearance. The basolateral amygdala (BLA) is a critical region of the limbic system involved in diverse emotional processing, and studies in human and AD animal models have reported that it is altered in early AD. However, whether synaptic and excitability properties are altered in the BLA in AD has not been studied. In this study, we used 6-month-old APP/PS1

The molecular mechanism of the antimalarial artemisinin and its derivatives is not yet fully understood, although these compounds are successfully used against Plasmodium protists. Other biological effects (anti-cancer or antinociceptive effects) are also possible following administration of artemisinin. Considering that Transient Receptor Potential (TRP) ion channels are key signalling molecules in many cancer and pain pathways, the aim of this study was to test whether members of this family are among the molecular targets of artemisinin. The effect of artemisinin on wild type or mutant TRP