Paternal exposure to voluntary exercise or corticosterone modifies the sperm long noncoding RNA profile, and their microinjection alters adult behavioural endophenotypes
Lucas Hoffmann, Baijia Li, Qiongyi Zhao, Wei Wei, Laura Leighton, Timothy Bredy, Terence Pang, Anthony Hannan · FENS Forum 2024
Previous studies in our lab showed that 4 weeks of paternal voluntary exercise in laboratory mice (C57Bl/6 strain) leads to lower anxiety levels and a more robust fear extinction memory in male adult offspring, whereas paternal corticosterone (stress hormone) exposure for 4 weeks leads to increased anxiety-related behaviours in male offspring, increased subordination towards other male mice, and increased attractiveness towards females. These behavioural changes were found to be accompanied by modulation of the paternal sperm small noncoding RNA profile, which is thought to be involved in the
ePoster · Neuroscience