Tau spreading in Alzheimer’s disease models is facilitated by the amyloid-β precursor protein
Magdalena Przybyla, Janet van Eersel, Sian Genoud, Miheer Sabale, Gabriella Chan, Matthew Chu, Annika van Hummel, Liming Hou, Julia van der Hoven, Esmeralda Paric, Astrid Feiten, Thomas Fath, Arne Ittner, Jillian J Kril, Greg T Sutherland, Yazi D Ke, Lars M Ittner · FENS Forum 2024
Alzheimer’s disease (AD) is characterised by the aberrant aggregation of two proteins within the brain- amyloid-β which deposits in extracellular plaques and the tau protein which forms neurofibrillary tangles. However, it is tau spreading that best correlates with clinical symptoms in AD, whilst the mechanisms that potentially drive tau spreading remain still unknown. More recently a study has demonstrated that binding of tau fibrils to the extracellular region of the Amyloid Precursor Protein (APP) led to the uptake of tau into cells, suggesting that APP may function as a tau fibril receptor
ePoster · Neuroscience