Upconversion-mediated transcranial optogenetics: Juggling with photons to control fear in mice
Jeremy Lesas, Jonathan Daniel, Thomas Bienvenu, Dalel El Marrouki, Juliette Vivien, Salwa Dhiba, Frédéric Lanore, Delphine Girard, Pierre Feugas, Eléonore Kurek, Airton Sinott Carvalho, Clément Hazet, Yann Humeau, Mireille Blanchard-Desce, Cyril Herry, Cyril Dejean · FENS Forum 2024
Although fear is known to serve essential purposes in protecting individuals from dangerous situations and threats, dysfunction of fear response can lead to neuropsychiatric disorders – such as pathological anxiety and post-traumatic stress disorder. The understanding of the neuropathophysiology of those disorders is still limited, and therapeutic options (psychotherapy or medication) remain in some cases ineffective. Works investigating the function of neuronal networks helped highlight the implication of the dorsomedial prefrontal cortex (dmPFC) in fear response. Moreover studies on mice hav
ePoster · Neuroscience