Topic: patience

We have revealed that there is a causal relationship between activation of dorsal raphe (DR) serotonergic neurons and patience when waiting for future rewards. To explain these behavioral data, we proposed a Bayesian decision model of waiting in which serotonin signals the prior probability of reward delivery. However, there is no direct evidence serotonin neural activity is modulated by reward probability. Five male serotonin neuron-specific GCaMP6-expressing mice were trained to perform a sequential tone-food waiting task that required them to wait for a delayed tone (tone delay: 0.3 s, tone