Topic: patient-derived monoclonal antibodies

Autoantibodies (aAb) against N-methyl-D-aspartate receptor (NMDAR) mediate autoimmune Anti-NMDAR encephalitis. This leads to the development of various symptoms, including seizures, memory deficits, cognitive dysfunction, and psychosis. Our current understanding of the pathophysiology remains limited. Particularly the crucial molecular insights of autoantibody recognition and the influence of their binding on the function of NMDARs. To address these knowledge gaps, we characterized three patient-derived monoclonal antibodies in a multi-modal approach, encompassing super-resolution microscopy,