A novel platform to embody and maintain in vitro neurons in simulated environments through real-time closed-loop electrophysiological recording and stimulation
Brett Kagan, Azin Azadi, David Hogan, Andrew Doherty, Alon Loeffler, Jackson Gritching, Habibollahi Forough, Candice Desouza, Finn Doensen, Glenn Kirilow, James Churchill, Jake Bowkett, Kwaku Dad Abu-Bonsrah, Brad Watmuff, Seung Hoon Byun, James Stewart, Hon Weng Chong · FENS Forum 2024
Advanced assemblies of hardware, software, and synthetic biology (wetware) have resulted in new methods to embody neural systems into simulated environments to elicit dynamic goal-directed activity (Kagan et al., 2023, Biotechnology Advances.). Evidence of learning from in vitro neurons was established in a simplified game of Pong through closed-loop real-time electrophysiological recordings and patterned stimulations via a system called DishBrain (Kagan et al., 2022. Neuron.). Analysis of dynamic activity changes within these networks revealed key correlates associated with the appearance of
ePoster · Neuroscience