Topic: pause neurons

Single cell activity of the basal ganglia, and the pallidal segments (GPe and GPi) in particular, has been well-characterized during deep brain stimulation (DBS) surgeries in unmedicated (“OFF state”) patients with Parkinson’s disease (PD). However, little is known about the effects dopaminergic medicine has on the individual cells’ activity in these structures. Here, we compared single cell recordings of the GPe and GPi of two medicated patients (“ON state”) with three patients in the OFF state. All patients suffered from late stage mixed PD. For the analysis, the neurons recorded during DBS