Topic: PB94

Histone deacetylase (HDAC) family proteins play important roles in pathological alterations of Alzheimer’s disease (AD). There has been keen interest in developing small molecule inhibitors of HDACs as potential therapeutics of AD. Presently, little is known about the role of HDAC11 in AD and whether HDAC11 can be a potential drug target for AD. Recently, we discovered PB94 as our lead small molecule inhibitor of HDAC11 exhibiting strong potency and selectivity against HDAC11 over other HDAC isoforms, which warranted further optimization and investigation for AD. Here, we optimized PB94 and an