Topic: PCA-ICA

Neurons in the cortico-basal ganglia circuit become excessively synchronised at beta frequencies (15-35 Hz) in Parkinson’s disease. However, it is unclear how this synchronised firing evolves across the network. Beta synchrony has often been assumed to emerge homogenously across the neurons within anatomical structures of the basal ganglia. However, it is possible that beta oscillations may emerge in a modular fashion within the neurons that make up an anatomical structure. We hypothesized that neurons in subregions of the basal ganglia preferentially reflect onset and offset of beta oscillati