Amyloid-β production and function are needed for cyclic nucleotides-mediated enhancement of synaptic plasticity and memory
Valeria Vacanti, Maria Rosaria Tropea, Roberta Carmela Trovato, Daniela Puzzo · FENS Forum 2024
The cyclic nucleotides (cNs) cAMP and cGMP are involved in the cellular mechanisms underlying long-term potentiation (LTP) and memory. Because a decrease of cNs is observed in aging and neurodegenerative disorders, including Alzheimer's Disease (AD), drugs restoring cNs levels, such as PDE inhibitors (PDE-Is), have been proposed as potential therapeutic strategies. Previous studies showed a crosstalk between cNs and amyloid-beta (Aβ), a peptide extensively known for its pathological role in AD but also implicated in the physiological processes of synaptic plasticity and memory.Based on these f
ePoster · Neuroscience