Topic: PDGF-CreERT

Calcium is a key intracellular messenger that regulates many vital cellular processes. Calcium signals in oligodendrocytes, the myelinating glia of the CNS, are known to translate environmental information to cellular processes such as proliferation, differentiation and myelination. Myelination is an adaptive process that depends on neuronal activity. We recently demonstrated that neuronal activity in vivo enhances remyelination in demyelinated lesions (Ortiz et al., 2019, JCI Insight). Here, we investigate whether calcium singal in oligodendroglia play a role in remyelination and whether beha