Modulation of the default mode network hub in the mouse brain by lysergic acid diethylamide: Insights from functional imaging
Anaïs Virenque, Henriikka Hovi, Rafael Moliner, Eero Castrén · FENS Forum 2024
Aims. Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We have recently found that lysergic acid diethylamide (LSD) directly bind to TrkB, the receptor for BDNF. Our data suggest that antidepressant and plasticity promoting-effect of psychedelics are mediated by TrkB. Our objective is to test in vivo the effect of LSD on brain functional connectivity, more specifically on the default mode network, and the impact of the modulation of TrkB receptor on this effect. Methods. Functional Ultrasou
ePoster · Neuroscience