Topic: pentameric glycine receptors

Optimal brain function relies upon the delicate equilibrium between excitatory and inhibitory neurotransmission. A slight disturbance in this equilibrium can trigger significant neurological disorders. In the mature brain, glycine assumes a dual responsibility by not only coordinating inhibitory processes through the activation of classical pentameric glycine receptors (pGlyRs), but also contributing to excitatory neurotransmission in its capacity as a co-agonist of N-methyl-D-aspartate receptors (NMDARs). The functional impact of glycine through pGlyRs has been extensively scrutinised, partic