Dissecting the impact of prenatal inflammation on astrocytes and Pentraxin 3
Giuliana Fossati, Cecilia Zen, Mariassunta De Luca, Anna Chiara Pacentra, Sonia Valentino, Angelo Iannielli, Eliana Lauranzano, Giulia Bertoni, Barbara Bottazzi, Cecilia Garlanda, Vania Broccoli, Michela Matteoli, Elisabetta Menna · FENS Forum 2024
Maternal infections and prenatal inflammation are recognized risk factors for neurodevelopmental diseases. Astrocytes are glial cells essential for synapse formation and refinement, but they also may react to inflammatory environment affecting neuronal network homeostasis. However, how an inflammatory episode occurring during fetal development influences astrocyte generation and phenotype remains largely unknown.In the brain, the innate immune molecule Pentraxin3 (PTX3) is produced by astrocytes and promotes the maturation of excitatory synapses. Its expression is induced by inflammatory stimu
ePoster · Neuroscience