Inferring Dynamics in Neural Recordings using LFADS with Per-trial Contextual Bias
Nishal Shah, Benyamin Meschede-Krasa, Erin Kunz, Nick Hahn, Foram Kamdar, Donald Avansino, Leigh Hochberg, Jaimie Henderson, David Sussillo · COSYNE 2025
Dynamical systems theory provides a promising framework for understanding neural activity. LFADS approximates neural recordings using a recurrent neural network (RNN) generator, but analyzing its dynamics has been challenging. We propose a simple modification to LFADS, adding a per-trial inferred bias, that dramatically improves interpretability by replacing complex multi-stable dynamics with simpler contextual dynamics. Both models were applied to neural activity recorded from macaque motor cortex during reaching movements. While the kinematic decoding was similar, they implemented contrasti
ePoster · Neuroscience