Topic: Perceived stress

Chronic psychosocial stress is a major etiological risk factor for major depressive disorder. Preclinical studies have shown that chronic stress can suppress adult neurogenesis in the dentate gyrus (DG). The primary goal of the present study was to test whether chronic stress and cortisol level translate into detectable changes in DG in humans. We recruited 55 participants without a history of psychiatric disorders. Clinical symptoms, perceived stress, and chronic stressors were rated on the Mood & Anxiety Disorders Symptom Questionnaire, Perceived Stress Scale, and Trier Inventory for Chr