Role of Na+/Ca2+ exchanger NCX in glioblastoma cell migration
Erica Cecilia Priori, Federico Brandalise, Francesca Giammello, Martino Ramieri, Daniela Ratto, Maria Teresa Venuti, Elisa Roda, Francesca Talpo, Paola Rossi · FENS Forum 2024
Glioblastoma (GBM) is the most malignant form of primary brain tumor. It is characterized by the presence of highly invasive cancer cells infiltrating the brain by interacting with astrocytes and endothelial cells. During invasion, GBM cells significantly shrink their volume and extend lamellipodia by modulating their membrane conductance repertoire. However, the changes in compartment-specific ionic dynamics involved in this process are still not fully understood. To investigate the alterations in the GBM cells membrane conductance during lamellipodia formation and migration, a battery of com
ePoster · Neuroscience