Topic: peri-infarct area

Stroke is the main cause of adult disability in developing countries. There is a need for identifying new signalling pathways involved in stroke pathogenesis to discover potential therapeutic strategies for stroke. We previously found that the E3 ubiquitin ligase APC/C-Cdh1 promotes neurogenesis, proliferation, and neuronal survival, which are essential events for brain repair after stroke. APC-Cdh1 also regulates protein levels of the dendrite stabilizer Rock2. Thus, the APC/C-Cdh1-Rock2 axis modulates dendrite elongation and synaptogenesis. However, whether Cdh1 plays a role in stroke remain