In vivo study of intercellular communication in a glioblastoma mouse model via connexin hemichannels
Viola Donati, Chiara Di Pietro, Chiara Peres, Chiara Nardin, Gina La Sala, Ferdinando Scavizzi, Daniela Marazziti, Marcello Raspa, Fabio Mammano · FENS Forum 2024
Glioblastoma is a highly malignant tumor with poor prognosis. Intercellular signaling has been proposed to be directly involved in glioblastoma proliferation, motility and invasion. In particular, (i) glioblastoma growth and infiltration are associated to deregulated astrocytes-neuron signaling; (ii) glioblastoma induces astrocytes function alterations leading to modification of the inter and intra cellular communication and neuronal hyperactivity and epileptic seizures; (iii) glutamate release in peri-tumoral region excite glutamate receptors on glioma cells promoting tumor growth and invasiv
ePoster · Neuroscience